Get Bioisosteres in Medicinal Chemistry, Volume 54 (Methods and PDF

By Nathan Brown

Written with the training medicinal chemist in brain, this is often the 1st smooth guide to systematically deal with the subject of bioisosterism.
As such, it presents a prepared reference at the rules and techniques of bioisosteric alternative as a key instrument in preclinical drug development.

the 1st half presents an outline of bioisosterism, classical bioisosteres and general molecular interactions that must be considered,
whereas the second one half describes a couple of molecular databases as assets of bioisosteric identity and explanation. The 3rd part
covers the 4 key methodologies for bioisostere identity and alternative: physicochemical homes, topology, form, and overlays of
protein-ligand crystal constructions. within the ultimate half, a number of real-world examples of bioisosterism in drug discovery tasks are discussed.

With its certain descriptions of databases, tools and real-life case reviews, this is often tailored for busy business researchers with little time for analyzing, whereas final simply obtainable to beginner drug builders as a result of its systematic constitution and introductory section.

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Bioisosteres in Medicinal Chemistry, Volume 54 (Methods and Principles in Medicinal Chemistry) by Nathan Brown


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