By Nathan Brown
As such, it presents a prepared reference at the rules and techniques of bioisosteric alternative as a key instrument in preclinical drug development.
the 1st half presents an outline of bioisosterism, classical bioisosteres and general molecular interactions that must be considered,
whereas the second one half describes a couple of molecular databases as assets of bioisosteric identity and explanation. The 3rd part
covers the 4 key methodologies for bioisostere identity and alternative: physicochemical homes, topology, form, and overlays of
protein-ligand crystal constructions. within the ultimate half, a number of real-world examples of bioisosterism in drug discovery tasks are discussed.
With its certain descriptions of databases, tools and real-life case reviews, this is often tailored for busy business researchers with little time for analyzing, whereas final simply obtainable to beginner drug builders as a result of its systematic constitution and introductory section.
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Extra info for Bioisosteres in Medicinal Chemistry, Volume 54 (Methods and Principles in Medicinal Chemistry)
Bioisosteres in Medicinal Chemistry, Volume 54 (Methods and Principles in Medicinal Chemistry) by Nathan Brown